Twenty Years Later
For two decades, Lloyd Christmas had remained in a catatonic state within the walls of a mental institution. His condition had reportedly begun after discovering that Mary Swanson, the object of his affections, had been married all along. During a routine visit, Harry Dunne, Lloyd’s lifelong best friend, had made a heartfelt plea for his recovery—only to learn that Lloyd had been faking his condition as an elaborate joke.
The Search for a Kidney
Harry had revealed that he was in need of a kidney transplant. Attempts to contact his biological family had failed after learning he was adopted. A pile of long-neglected mail from Harry’s father had been given to him, and among it was a decades-old postcard from Fraida Felcher, a former girlfriend, claiming she had been pregnant and needed to talk.
Upon calling her, Fraida had disclosed that she had given birth to a daughter named Fanny, later adopted and renamed Penny by her new parents. Fraida had once written to reconnect with Penny, but a letter had been returned with a warning never to reach out again.
A New Lead in Maryland
With the hope of finding a kidney donor, Harry and Lloyd had embarked on a journey to Oxford, Maryland. There, they had met Dr. Bernard Pinchelow and his wife Adele—Penny’s adoptive parents. Penny had already left for El Paso, Texas, to present a speech at the KEN Convention, an event meant to honor her father’s achievements.
An important package, containing what Bernard described as a billion-dollar invention, had been left behind by Penny. Adele had suggested that Harry and Lloyd deliver the package in her place. Unknown to them, Adele had been plotting to poison Bernard for his fortune and had enlisted the help of her lover, the family’s housekeeper Travis Lippincott.
Trouble on the Road
Travis had joined the road trip, intending to retrieve the package for Adele. His patience had worn thin due to the duo’s antics. After a prank nearly killed him, an attempt had been made on their lives. However, Travis had perished in a train collision during his own failed assassination attempt.
Adele had received word of Travis’s death and enlisted his identical twin, Captain Lippincott, a military veteran, to eliminate Harry and Lloyd.
Arriving at the Convention
The convention had been in full swing when Harry and Lloyd arrived. Harry had impersonated Dr. Pinchelow and had been admitted. Tensions had flared when Harry learned that Lloyd had developed romantic feelings for Penny. Lloyd had been ejected from the convention for lacking credentials.
Outside, a phone call had reconnected Lloyd with Penny, and a meeting had been arranged at a local restaurant. There, Lloyd had convinced himself that he, not Harry, must be Penny’s real father.
Confrontation and Chaos
Meanwhile, Adele and Captain Lippincott had arrived and accused Harry of fraud in front of the convention’s leadership. Fraida and Penny had been denied entry, prompting Fraida to pull the fire alarm, causing mass evacuation.
As chaos unfolded, Harry had encountered both women, only for the trio to be cornered at gunpoint by Adele and Lippincott. Lloyd had reappeared with news: he had traveled to Mexico and undergone kidney removal surgery to donate one to Harry.
The Truth Revealed
At that moment, FBI agents had raided the scene. Bernard had arrived, revealing he had long suspected Adele’s plot. The mysterious package had been revealed to contain only cupcakes. Fraida had learned that Adele, not Penny, had written the rejection letter.
Enraged, Adele had attempted to shoot Penny, but Harry had stepped in and taken the bullet, surviving the wound. Adele and Lippincott had been arrested on the spot.
Final Revelations
At the hospital, Harry had admitted that his kidney crisis had been fabricated as part of a prank. It was then revealed that the organ Lloyd had sacrificed was not a kidney but a pork chop, signaling that he had been deceived by foreign doctors.
Fraida had delivered one final revelation: Penny’s biological father had been neither Harry nor Lloyd, but their deceased high school friend, Peter “Pee-Stain” Stainer. It had also been clarified that Fraida had never slept with either of them.
Back on the Road
With their adventure concluded and their hopes dashed, the two friends had begun their journey home from El Paso. On their way, they had encountered two attractive women. Rather than engage, the duo had pushed them into nearby bushes and gleefully shouted, “Bush Club,” before running off and exchanging high-fives.
Post-Credits Scene
In a final twist, a pair of milkshakes had been flung onto a moving truck’s windshield. The driver had been revealed as Sea Bass, the trucker from their earlier misadventures. His anger had reignited as he swerved to pursue them. A parody trailer had followed, teasing a fictional sequel titled Dumb and Dumber For, with Captain Lippincott emerging from the screen in camouflage before vanishing off-screen.
